Journal article
Epidemiological, immunological and virulence characteristics of persistent Streptococcus pneumoniae vaccine serotypes following vaccine introduction.
Paige Skoko, Sam Manna, Laura K Boelsen, Jason Hinds, Stephanie W Lo, Casey L Pell, Belinda D Ortika, Rachel A Higgins, Vicki Bennett-Wood, Hanwen Hou, Odgerel Tundev, Eileen M Dunne, Cattram D Nguyen, Fiona M Russell, E Kim Mulholland, Tuya Mungun, Paul V Licciardi, Claire von Mollendorf, Stephen D Bentley, Catherine Satzke
Nat Commun | Published : 2026
Open access
Abstract
Streptococcus pneumoniae vaccine serotypes can persist despite pneumococcal conjugate vaccine (PCV) introduction. To examine serotype persistence, we leverage 6,545 nasopharyngeal swabs collected from children hospitalised with pneumonia before and after PCV13 introduction in Mongolia. DNA microarray was used to identify changes in lineage composition within serotypes 6A, 6B, 14, 19F and 23F over the six-year surveillance period. Children carrying post-PCV lineages are less likely to have severe pneumonia (serotypes 6B, 14 and 19F) and be multi-drug resistant (serotypes 6A, 6B and 23F) than pre-PCV lineages. Of note, the post-PCV lineage of serotype 6B has lower antibody binding to capsule a..
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Grants
Awarded by Department of Health | National Health and Medical Research Council (NHMRC)